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At the book’s core lies a quiet but radical idea: matter does not merely serve human thought; it participates in how we think, build, and understand our environments. Fibers, surfaces, and tools from tree bark, fungi, and wool to digital data and clouds become active partners in perception and design processes, co-producing knowledge across laboratories, workshops, studios, and archives, and opening new pathways for human–material interaction. Emerging from the Berlin-based Matters of Activity Cluster of Excellence, this volume assembles case studies, essays, and material experiments conducted across the natural sciences, humanities, and design. The underlying collaborative research rethinks materiality as relational, historically situated, and actively shaping the world we inhabit.