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In this landmark work of natural history, Boyce Upholt tells the epic story of this wild and unruly river, and the centuries of efforts to control it. Over thousands of years, the Mississippi watershed was home to millions of Indigenous people who regarded “the great river” with awe and respect, adorning its banks with astonishing spiritual earthworks. The river was ever-changing, and Indigenous tribes embraced and even depended on its regular flooding. But the expanse of the watershed and the rich soils of its floodplain lured European settlers and American pioneers, who had a different vision: the river was a foe to conquer.